Miami DEA agent Cliff Adams is in South America working undercover for Gonzalo Reyes, the biggest cocaine exporter in South America. Cliff's fiancée, Janet Meade, is a reporter doing a story about Reyes. Reyes orders Cliff to kill Marcelo Villalba, who is running for his countries position as president, but Cliff can't bring himself to do it, because his assignment from the DEA is to work against Reyes. Reyes is afraid Villalba will put him out of business, and is afraid that Janet's story will do the same thing, so Reyes sends someone else after Villalba, and then Reyes has Janet kidnapped, and Cliff is the only one who can keep Reyes' plans from succeeding.

At the age of 17, Griselda Blanco, made her way to the U.S. with a fake passport with her first husband Carlos. Living in Queens with her three sons, Griselda became enticed by the money the drug world offered, and quickly became embroiled with local drug runners. Griselda masterminded the use of beautiful women, the elderly and children as the mules and created false-bottom suitcases to smuggle cocaine from Colombia.

A rock band is on the brink of super-stardom. Until now they've juggled their music career with cocaine smuggling. The musicians and their manager wish to sever ties with organized-crime, leave the drug world behind and concentrate on music. They are coerced into doing one last job for the Mob. They lose the $2 million of cocaine and find themselves marked men unless they can fulfill their obligations.

A Black Cougar high on cocaine escapes an animal testing facility and wreaks havoc on Los Angeles.

Law abiding sisters Alani and Veronica stubble onto a large stash of cocaine and intend to do the right thing, but somehow end up on a dangerous adventure into the dark underbelly of the Los Angeles drug world.

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